Title: Department of Radiation Biology Descriptive info: .. Home.. News.. Research.. Collaborators.. Personel.. Jobs.. Useful links.. Contact.. Posters.. Latest Publications.. Dissertations.. Welcome to Department of Radiation Biology.. The Department of Radiation Biology is a cancer research laboratory within the Oncology Clinic,.. Finsen Center.. , and part of The Copenhagen Cell Biology and Cancer Research network (The CCC Network Project) within the Faculty of Medicine,.. University of Copenhagen.. The Finsen Center is a center organized under the Copenhagen University Hospital,.. Rigshospitalet.. Rigshospitalet is part of a regional corporation of hospitals - the.. Copenhagen Hospital Corporation (RegionH).. Financial Support.. The research at the Department of Radiation ... should be addressed to our e-mail, which can be found in the list of personel.. We can also be contacted by phone:.. For clinical enquiries contact Else Filrup Pedersen; Phone: +45 3545 4608.. For laboratory enquiries contact Mette Villingshøj; Phone: +45 3545 6329.. Telefax: +45 3545 6301.. 22/10-2012.. The laboratory has received a research grant from Aase og Ejnar Danielsens.. 26/09-2012.. The laboratory has received a research grant from Kong Christian d.. Tiendes.. 04/09-2012.. The laboratory has received a research grant from Eva og Henry Frænkels.. The Finsencenter, Section 6321, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark..
Title: Latest news - Department of Radiation Biology Descriptive info: >.. Latest news.. News Archive.. 10/22-2012.. The laboratory has received a research grant from Aase og Ejnar Danielsens Fond.. 09/26-2012.. Tiendes Fond.. 09/04-2012.. The laboratory has received a research grant from Eva og Henry Frænkels Mindefond.. 07/30-2012.. The laboratory has received a research grant from Fabrikant Einar Willumsens Mindelegat.. The laboratorium has received a research grant from Katrine & Vigo Skovgaards Fond..
Title: Research - Department of Radiation Biology Descriptive info: Current Projects.. Lung Cancer - SCLC.. Neuro-Oncology.. General.. The general intend of the laboratory is to study molecular and phenotypic features of Lung Cancer and Brain Tumors.. Above all, growth factor receptor studies are of interest.. The primary aim is to generate more insight into the influence of these growth factors on the malignant phenotype of cancer cells, and the secondary aim to extend that ... as well as suggesting new translational treatment modalities viz.. targeting therapy and inhibition of signal transduction.. The use of the most recent technology within molecular biology for gene and gene product investigation has made it possible to reveal the similarities between tumors and not merely their differences.. This advance is the reason why targeted therapy for cancer patients may provide a potential form of treatment..
Title: Useful links - Department of Radiation Biology Descriptive info: Useful links.. Lung Cancer.. International Association for the Study of Lung Cancer.. Lung Cancer- a program of Cancer Care.. Lung Cancer: Information from the National Cancer Institute.. Lung Cancer Online.. Epidermal Growth Factor Receptor.. EGFR-info.. com.. Brain Tumors.. The American Brain Tumor Association.. The Society for Neuro Oncology.. Organizations, Denmark.. Dansk Lunge Cancer Gruppe.. Gruppe SKA - Sammenslutningen af Kræftafdelinger Co-operative Cancer ... Research and Treatment of Cancer.. ESMO - European Society for Medical Oncology.. ESTRO - European Society for Therapeutic Radiology and Oncology.. ESGT - European Society of Gene Therapy.. Organizations, USA.. AACR - American Association for Cancer Research.. ASCO - American Society for Clinical Oncology.. ASGT - American Society of Gene Therapy.. NCI - National Cancer Institute.. RTOG - Radiation Therapy Oncology Group..
Title: Contact - Department of Radiation Biology Descriptive info: For clinical enquiries: Else Filrup Pedersen: +45 3545 4608.. For laboratory enquiries: Mette Villingshøj: +45 3545 6329.. Address.. The Finsen Centre - Section 6321.. Copenhagen University Hospital.. Blegdamsvej 9.. DK-2100 Copenhagen.. Denmark.. Find us.. Click.. here.. to see a map of Rigshospitalet.. to see map of area around Rigshospitalet and directions..
Title: Posters - Department of Radiation Biology Descriptive info: Previous Posters.. 2012.. This poster was presented at American Association for Cancer Research.. (AACR), Annual Meeting 2012 in Chicago, USA by Karina Kristoffersen, MSc,Ph.. D.. student at the Department of Radiation Biology.. (click here to view poster in pdf format).. (AACR), Annual Meeting 2012 in Chicago, USA by Signe Regner, MSc,Research Assistant at the Department of Radiation Biology.. (AACR), Annual Meeting 2012 in Chicago, USA by Chris Juul Hedegaard, Post doc at the Department of Radiation Biology.. 2011.. This poster was presented at the 2011 SNO Society for Neuro-Oncology Annual Scientific Meeting and Education Day, Orange County, California, USA by Kenneth Hofland MD, Ph.. At Dept.. of Oncology and Dept.. of Radiation Biology.. (.. click here to view poster in pdf format).. This poster was presented at the 2011 SNO Society for Neuro-Oncology Annual Scientific Meeting and Education Day, Orange County, California, USA by Søren Møller MD, Ph.. student at Dept.. of Radiotherapy and Dept.. click here to view poster in pdf format.. ).. This poster was presented at The Notch Meeting V, Athens, Greece, by Karina Kristoffersen, MSc, PhD-student at the Department of Radiation Biology.. This poster was presented at the annual meeting of the Danish Association for Clinical Oncology (DSKO), Nyborg, Denmark and at the 24th annual Meeting of the Danish Association for Cancer Research, Charlottenlund, Denmark, by Karina Kristoffersen, MSc, PhD-student at the Department of Radiation Biology.. 2010.. This poster was presented at the 2010 Society for Neuro-Oncology Annual Meeting, Montreal, Canada, by Søren Møller MD, now Ph.. This poster was presented at the 15th annual scientific meeting of the.. Society for Neuro-Oncology (SNO), Montreal, Canada, 2010 by Karina.. Kristoffersen, MSc, PhD-student at the Department of Radiation Biology.. This poster was presented at the ASGCT (American Society of Gene Cell.. Therapy) 13th annual meeting, Washington DC, USA, 2010 and at the 23th annual.. Meeting of the Danish Association for Cancer Research, Charlottenlund, Denmark, 2010, by Frederik Cramer, PhD student at Department of Radiation Biology.. This poster was presented at the ASGCT (American Association of Gene and Cell Therapy) 13th annual meeting, Washington DC, USA, May 2010 by Camilla Laulund Christensen, Phd-student at Department of Radiation Biology.. This poster was presented at the PhD.. Day 2010 at the Faculty of Health Sciences, University of Copenhagen, Denmark, at the Symposium for Young Scientific Investigators 2010 at Copenhagen University Hospital (FYF), Copenhagen, Denmark and at the 23th annual Meeting of the Danish Association for Cancer Research, Charlottenlund, Denmark.. By Karina Kristoffersen, MSc, PhD-student at the Department of Radiation Biology.. This poster was presented at the EMBO workshop, Cell guidance signals in.. cancer held at Camogli-Portofino Vetta, Italy in May 2010 by ... small cell lung carcinoma.. This poster was presented at American Society of Gene Therapy (ASGT),.. Annual Meeting in San Diego, USA, in May 2009 by Frederik Cramer, Research.. Assistant at Department of Radiation Biology.. Optimization of non-viral gene delivery to the nucleus for small cell lung.. cancer gene therapy.. This poster was presented at American Society of Gene Therapy.. (ASGT), Annual Meeting in San Diego, USA, in Maj 2009 by Camilla Laulund Christensen, Ph.. d.. student at Department of Radiation Biology.. The suicide fusion gene YCD-YUPRT induces high and specific cytotoxicity in small cell lung cancer cell lines and tumor growth delay in xenografts when regulated from a cancer-specific promoter.. (AACR), Annual Meeting 2009 in Denver, USA, in April 2009 by Alice.. Bjerregaard Larsen, Phd-student at Department of Radiation Biology.. Activated EGFR induce trans-phosphorylation of EphA2 in cancer cells.. click here to view poster in pdf-format.. 2008.. Poster presentation at the Society for Neuro-Oncology (SNO) Scientific.. Annual meeting in Las Vegas, USA, in november 2008.. Presented by Benedikte.. Hasselbalch M.. D and PhD student at Department of Radiation Biology.. The poster shows the mature data from the clinical phase II protocol investigating the effect of.. the EGFR inhibitor cetuximab (Erbitux) in combination with the VEGFR.. inhibitor bevacizumab (Avastin) and Irinitecan.. This poster will be presented by Chief Physician, Ulrik Lassen, MD, Ph.. D, at the American Society for Clinical Oncology Yearly meeting in Chicago, June, 2008.. It represents the first results ever published of this combination in patients with Glioblastoma Multiforme.. The patients were treated with Cetuximab - a EGFR inhibitor -, Avastin - a VEGFR inhibitor - and Irenotecan.. The function of normal and mutated epidermal growth factor receptors in Glioblastoma Multiforme - Establishment of an in vivo and in vitro model.. A chimeric fusion of the human Achaete Scute Homolog 1 and Enhancer of Zeste Homolog 2 promoters is a promising regulator of suicide gene therapy for small cell lung cancer.. Identification of tumour-suppressor-gene candidates in small cell lung cancer, which alone or combined with a p53-reactivating molecule, can be used for cancer gene therapy.. Potential of therapeutic genes for small cell lung cancer gene therapy.. 2007.. Transcriptionally targeted cancer gene therapy for small cell lung cancer.. The role of EphA2 in EGF-induced cancer cell proliferation and motility.. The function of normal and mutated epidermal growth factor receptors in Glioblastoma Multiforme - Establishment of an in vivo model.. Improved response by co-targeting EGFR/EGFRvIII and c-Src.. EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells.. Identification of novel tumor suppressor genes specific for small cell lung cancer and primary glioblastoma multiforme..
Title: Latest Publications - Department of Radiation Biology Descriptive info: Cramer F, Christensen CL, Poulsen TT, Badding MA, Dean DA, Poulsen HS:.. Insertion of a Nuclear Factor Kappa B DNA Nuclear Targeting Sequence potentiates.. suicide gene therapy efficacy in lung cancer cell lines.. Cancer Gene Therapy Oct;19(10):675-83.. 2012.. (click here to open pubmed link).. Møller S, Grunnet K, Hansen S, Schultz H, Holmberg M, Sorensen M, Poulsen HS, Lassen U: A phase II trial with bevacizumab and irinotecan for patients with primary brain tumors and.. progression after standard therapy.. Acta Oncol.. Jul;51(6):797-804, 2012.. (click here to open pubmed link).. Michaelsen SR, Christensen CL, Sehested M, Cramer F, Poulsen TT, Patterson AV, Poulsen HS.. : Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemo-resistant small cell lung cancer (SCLC) cells.. J Gene Med.. Jul;14(7):445-58, 2012.. (click here to open pubmed link).. Stockhausen MT, Kristoffersen K, Poulsen HS: Notch signaling and brain tumors.. Adv Exp Med Biol.. 727:289-30, 2012.. Poulsen HS, Von der Maase H.. : MiRNA ved glioblastomer - potentiale og begrænsninger.. Ugeskr.. Læger,Marts 5; 174(10): 628, 2012.. (click here to open link).. Nedergaard MK, Hedegaard CJ, Poulsen HS: Targeting the Epidermal growth factor receptor in solid tumor malignancies.. BioDrugs: Apr 1;26(2):83-99.. (click here to open pubmed link.. Zandi R, Xu K, Poulsen HS, Roth JA and Ji L: The effect of adenovirus-mediated gene expression of FHIT in small cell lung cancer cells.. Cancer Investigation, 29(10):683 691, 2011.. Gjetting T, Andresen TL, Christensen CL, Poulsen TT, Cramer F, Poulsen HS : A simple protocol for preparation of a liposomal vesicle with encapsulated plasmid DNA that.. mediate high accumulation and reporter gene activity in tumor tissue.. Results in Pharma Sciences 1 (2011): 49-56.. (click here to read article).. Stockhausen MT, Broholm H, Villingshøj M, Kirchhoff M, Gerdes T, Kristoffersen K, Kosteljanetz M, Spang-Thomsen M, and Poulsen HS: Maintenance of EGFR and EGFRvIII expression in an in vivo and in vitro model of human glioblastoma multiforme.. Experimental Cell Research 2011.. Jul 1; 317(11):1513-26.. Zandi R, Selivanova G, Christensen CL, Gerds TA, Willumsen BM, Poulsen HS: PRIMA-1.. Met.. /APR-246 induces apoptosis and tumor growth delay in Small Cell Lung Cancer expressing mutant p53.. Clin Cancer Research, 2011 May 1; 17(9):2830-41.. Denholt C, Binderup T, Stockhausen MT, Poulsen HS, Spang-Thomsen, Hansen PR, Gillings N, Kjær A: Evaluation of 4-[18F]fluorobenzoyl-FALGEA-NH2 as a Positron Emission Tomography tracer for epidermal growth factor receptor mutation variant III imaging in cancer.. Nuclear Medicine and Biology.. 2011 May; 38(4):509-15.. Henriksson R, Asklund T, Poulsen HS: Impact of therapy on quality of life, neurocognitive function and their correlates in Glioblastoma Multiforme.. J.. Neurooncol.. 2011 Apr 6.. Jakobsen JN, Hasselbalch B, Stockhausen MT, Lassen U, Poulsen HS: Irinotecan and bevacizumab treatment of recurrence of Glioblastoma Multiforme.. Expert Opinion On Pharmacotherapy, 2011.. 2011 Apr;12(5):825-33.. Hasselbalch B, Lassen U, Poulsen HS.. Patients with Recurrent High-Grade Glioma.. Therapy with Combination of Bevacizumab and Irinotecan.. In: M.. A.. Hayat, Tumors of the central nervous system.. Volume 2.. Springer 2011, pp 289-301.. Stockhausen MT, Kristoffersen K, Poulsen HS.. Notch Signaling and Brain Tumors.. In: Reichrath J and Reichrath S.. Notch Signaling in Embryology and Cancer.. Landes Bioscience and Springer, 2011.. Olszewski U, Poulsen TT, Ulsberger E, Poulsen HS, Geissler K, Hamilton G.. In vitro cytotoxity of combinations of dichloroacetate with anticancer platinum compounds.. Clinical Pharmacology.. Advances and Applications 2010:2 1-7.. Gjetting T, Arildsen NS, Christensen CL, Poulsen TT, Roth JA, Handlos VN, Poulsen HS.. In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection.. Int.. Nanomedicine 2010, Aug 9;5:371-83.. click here to open pubmed link.. Hasselbalch B, Eriksen JG, Broholm H, Christensen IJ, Grunnet K, Horsman MR, Poulsen HS, Stockhausen MT, Lassen U.. Prospective evaluation of angiogenic, hypoxic and EGFR related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan.. APMIS 2010 Aug.. Bartkova J, Hamerlik P, Stockhausen MT, Ehrmann J, Hlobilkova A, Laursen H, Kalita O, Kolar Z, Poulsen HS, Broholm H, Lukas J, Bartek J.. Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas.. Oncogene.. 2010 Jun 28.. Hasselbalch B, Lassen U, Poulsen HS, Stockhausen MT.. Cetuximab Insufficiently Inhibits Glioma Cell Growth Due to Persistent EGFR Downstream Signaling.. Cancer Invest.. 2010 May 26.. Madsen K, Poulsen HS.. Needs for everyday life support for brain tumour.. patients relatives: systematic literature review.. Eur J Cancer Care (Engl).. 2010 Apr ... Hansen HH, Informa Healthcare, London, UK.. Poulsen TT, Pedersen N, Juel H, Poulsen HS.. A chimeric fusion of the hASH1 and EZH2 promoters mediates high and specific reporter and suicide gene expression and cytotoxicity in small cell lung cancer cells.. Cancer Gene Therapy, 15 (9):563-75.. Andersen P, Pedersen MW, Woetmann A, Villingshøj, M, Stockhausen M, Ødum N and Poulsen HS.. Cancer, 122(2):342-9, 2008.. Zandi R, Larsen AB, Andersen P, Stockhausen MT, Poulsen HS.. Mechanisms for Oncogenic Activation of the Epidermal Growth Factor Receptor.. Cellular Signalling, 19(10): 2013-2023, 2007.. Grandal MV, Zandi R, Pedersen MW, Willumsen BM, Van Deurs B, Poulsen HS.. EGFRvIII escapes downregulation due to impared internalization and sorting to lysosomes.. Carcinogenesis, 28(7):1408-17, 2007 (.. Larsen AB, Pedersen MW, Stockhausen M, Grandal MV, van Deurs B, Poulsen HS.. Activation of the EGFR target gene EphA2 inhibits EGF-induced cancer cell motility.. Mol Cancer Res, Mar;5(3):283-293, 2007.. N.. Pedersen, T.. T.. Poulsen, H.. Skovgaard Poulsen.. Cre/loxP recombination vectors for promoter studies.. Electron J Biotechol, 10:315-321, 2007.. click here to read article.. 2006.. Villingshoj M, Ross L, Thomsen BL, Johansen C.. Does marital status and altered contact with the social network predict colorectal cancer survival? Eur J Cancer.. Nov;42(17):3022-7, 2006.. Spindler K-LG, Olsen DA.. Nielsen JN, Brandslund I, Poulsen HS, Villingshøj M, Jakobsen A.. Lack of the Type III Epidermal Growth Factor Receptor Mutation in Colorectal Cancer.. Anticancer Res.. , Nov-Dec; 26(6C):4889-4893, 2006.. Andersen PB, Blinkenberg M, Lassen U, Kosteljanetz M, Wagner A, Poulsen HS, Sorensen PS, Paulson OB.. A prospective PET study of patients with glioblastoma multiforme.. Acta Neurol Scand, 113(6):412-8, 2006.. Poulsen HS.. Gliomer hos voksne: Primær ikke-kirurgisk behandling.. Ugeskr Læger, 168(47):4082, 2006.. Pedersen M.. W.. , Poulsen HS.. Mutationer i EGF receptoren: struktur og tumorbiologisk relevans.. Ugeskr Læger, 168:2354-2361, 2006.. Vestergaard, M.. Pedersen, N.. Pedersen, C.. Ensinger, Z.. Tümer, N.. Tommerup, H.. Skovgaard Poulsen, L.. Larsen: Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.. Lung Cancer, 52:281-90, 2006.. Pedersen, S.. E.. Hansen, A.. V.. Heydenreich, H.. G.. Kristensen, H.. Skovgaard Poulsen: Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands.. Eur J Pharm Biopharm, 62:155-162, 2006.. Pedersen N, Pedersen MW, Lan MS, Breslin MB, Poulsen HS.. The Insulinoma-Associated 1: a Novel Promoter for Targeted Cancer Gene Therapy for Small Cell Lung Cancer.. Cancer Gene Ther, 13:375-384, 2006.. 2005.. Pedersen MW, Pedersen N, Ottesen, LH, Poulsen HS.. Differential response to gefinitib of cells expressing normal EGFR and the mutant EGFRvIII.. Br J Cancer, 93:915-23, 2005.. Poulsen TT, Pedersen N, Perin MS, Hansen CK, Poulsen HS.. Specific sensitivity of small cell lung cancer cell lines to the snake venom Toxin, Taipoxin.. Lung Cancer, 50 (3):329-337, 2005.. Pedersen MW, Pedersen N, Damstrup L, Villingshøj M, Sønder SU, Rieneck K, Bovin LF, Poulsen HS.. Analysis of the epidermal growth factor receptor specific transcriptome: effect of expression level and an activating mutation.. J Cell Biochem, 96(2):412-27, 2005.. (click here to read supplementary data) (.. H.. Collatz Christensen, J.. Schüz, M.. Kosteljanetz, H.. Skovgaard Poulsen, J.. D.. Boice, Jr.. , J.. K.. McLaughlin and C.. Johansen.. Cellular telephones and risk for brain tumors.. Neurology, 64:1189-1195, 2005.. Poulsen TT, Pedersen N, Poulsen HS.. Replacement and suicide gene therapy for targeted treatment of lung cancer.. Clinical Lung Cancer, 6(4): 227-236, 2005.. 2004.. Pedersen N, Pedersen MW, Poulsen TT, Mortensen S, Sørensen SB, Rieneck K, Bovin LF, Poulsen HS.. New targets and treatment of small cell lung cancer.. Chest.. 125: 154S, 2004.. Collatz HC, Schüz J, Kosteljanetz M, Poulsen HS, Thomsen J, Johansen C.. Cellular telephone use and risk for acoustic neurinoma.. Am J Epidemiol.. 159(3): 277-83, 2004.. Pedersen MW, Tkach V, Pedersen N, Berezin V and Poulsen HS.. A naturally occuring constitutive active variant of the epidermal growth factor receptor increases cell motility.. Cancer 108:943-653, 2004.. 2003.. Heidenreich AV, Westmeier R, Pedersen N, Poulsen HS, Kristensen HG.. Preparation and purification of cationic nanospheres - effects on particle size, physical stability and cell toxicity.. Pharm.. 254:83-87, 2003.. Schimiegelow M, Feldt-Rasmussen U, Rasmussen AK, Lange M, Poulsen HS, Müller J.. Assessment of the Hypothalamo-Pituitary-Adrenal Axis in Patients treated with Cranial Radiotherapy for a Childhood Brain Tumor.. J Clin Endocrinol Metab.. Jul.. 88(7):3149-54, 2003.. Nielsen KL, Allen MR, Bloomfield SA, Andersen TL, Chen X, Xu T, Poulsen HS, Young MF, Heegaard M.. Biglycan Deficiency interferes with overiectomy-induced bone loss.. J Bone Miner Res.. 18(12):2152-2158, 2003..
Title: Dissertations - Department of Radiation Biology Descriptive info: Ph.. 1.. Lars Damstrup.. Receptors for growth factors TGFa and TGFb in human small cell lung cancer.. 1-65, 1993.. 2.. Peter Nørgaard.. The effect of treatment of small cell lung cancer cell lines with Transforming Growth Factor-b.. 1-64, 1996.. 3.. Ulrik Lassen.. Positron emission tomography (PET) of malignant Tumors.. 1-82, 1998 (In collaboration with Oncology Clinic, Finsencenter).. 4.. Susanne Hougaard.. Inactivation of Transforming Growth Factor b type II receptor in small cell lung cancer.. 1-70, 1999.. 5.. Marianne Krarup.. Cell cycle regulating factors in small cell lung cancer.. 1-83, 2001.. 6.. Mikkel Wandahl Pedersen.. The Type III Epidermal Growth Factor Recetor Mutation in Cancer.. 1-156, 2003.. 7.. Karina Jensen.. Betaglycan og osteoporose.. 1-70, 2004.. 8.. Thomas Tuxen Poulsen.. Gene Therapy for Small Cell Lung Cancer - Targeting the Neuroendocrine Phenotype 1-145, 2008.. To download the thesis click.. 9.. Helle Collatz Christensen.. Cellular telephones and the risk of brain tumors (in collaboration with The Danish Cancer Society and Department of Neurosurgery, Rigshospitalet).. 1-48, 2006.. 10.. Benedikte Hasselbalch.. Effects of EGFR and VEGF inhibition in Human Glioblastomas using Cetuximab and Bevacizumab.. 1-158, 2010.. 11.. Alice Bjerregaard Larsen.. Interaction between EGFR and EphA2 - Regulation and functionel significance in human cancer.. ... Expressed Genes Mediated by The Type III Epidermal Growth Factor Receptor Mutation.. 1-99, 2000.. Mads Meltorn.. A protein tyrosine kinase profile and matrigel invasion of a small cell lung cancer cell line transfected with a mutant epidermal growth factor receptor.. 1-69, 2000.. Gitte Pontoppidan.. Profile of Differentially Expressed Genes Mediated by The EGFRvIII in a Glioblastoma Cell Line and Corresponding Xenograft.. 1-84, 2002.. Betydninger af ændringer i det sociale netværk for overlevelse blandt patienter med kolorektalcancer.. 1-45, 2002.. Receptor Candidates for Targeted Treatment of small cell Lung Cancer.. 1-78, 2004.. Alice Bjerregård.. The Epidermal Growth Factor Receptor Induces the Expression of the Receptor Tyrosine Kinase EPHA2.. 1-81, 2005.. Investigation of EGFRvIII Downregulation.. 1-121, 2005.. Peter Andersen.. Role of the tumor suppressor IRF-1 activated by the epidermal growth factor receptor in human cancer cells.. 1-81, 2006.. Therapeutic Genes for Small Cell Lung Cancer Gene Therapy.. 1-83, 2007.. Optimization of non-viral gene delivery to the nucleus for small cell lung cancer gene therapy.. 1-79, 2009.. A functional study of Notch.. signaling in brain cancer stem-like cells.. 1-106, 2009.. Signe Regner Michaelsen.. Influence of resistance on the therapeutic potential of transcriptionally targeted Suicide Gene therapy for Small Cell Lung Cancer.. 1-94, 2011..